期刊
TETRAHEDRON LETTERS
卷 50, 期 31, 页码 4488-4491出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2009.05.044
关键词
Biotinylated CD22 ligand; Hanessian reaction; Click chemistry
资金
- ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan [17101007]
- CREST of JST (Japan Science and Technology Corporation)
- Grants-in-Aid for Scientific Research [17101007] Funding Source: KAKEN
Biotin conjugate of the most potent ligand for mouse CD22 was designed and synthesized. The key synthetic step involved the dual capability of Hanessian reaction for debenzylation and simultaneous conversion of the anomeric p-methoxyphenyl group into the corresponding phenylthioglycoside in one step. Competition enzyme-linked immunosorbent assay (ELISA) for testing the binding affinity of synthetic sialosides was developed based on this biotinylated ligand. (C) 2009 Elsevier Ltd. All rights reserved.
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