期刊
TETRAHEDRON LETTERS
卷 50, 期 37, 页码 5190-5193出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2009.06.108
关键词
Aldol condensation; Candida antarctica lipase B; Non-aqueous media; Tricyclic 1,3-diketone; Vinyl acetate
资金
- Department of Science and Technology (DST), Govt. of India [435]
- CSIR, India
- Department of Biotechnology (DBT), Govt. of India
Novozym 435 (a commercially available immobilized form of Candida antarctica lipase B) was found to catalyze a condensation reaction of 5-hydroxy-endo-tricyclo[5.2.1.0(2,6)]deca-4,8-dien-3-one with acetaldehyde (enzymatically produced from vinyl acetate in situ) under low water conditions, in presence of 10% organic co-solvent (N,N-dimethyl formamide or pyridine), to form a bis-adduct. Even though the condensation reaction occurred with pyridine (acting as a base catalyst) in the presence of acetaldehyde and in the absence of enzyme, the reaction was very slow as compared to the enzymatic process. Thus, while the non-enzymatic process took 4 days to achieve 100% conversion; in presence of enzyme it was possible within 4 h. (C) 2009 Elsevier Ltd. All rights reserved.
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