4.4 Article

Construction of a new type of chiral bidentate NHC ligands: copper-catalyzed asymmetric conjugate alkylation

期刊

TETRAHEDRON LETTERS
卷 50, 期 33, 页码 4741-4743

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PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2009.06.026

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资金

  1. Advanced Molecular Transformations of Carbon Resources and Specially Promoted Research [18037056]
  2. Ministry of Education, Culture, Sports, Science and Technology, Japan [18002011]
  3. Grants-in-Aid for Scientific Research [18037056] Funding Source: KAKEN

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We synthesized in three steps simple chiral bidentate NHC Compounds that carry an achiral coordinating group as N-substituent and revealed that they serve as efficient chiral auxiliaries for the copper-catalyzed asymmetric conjugate addition of dialkylzinc to acyclic enones (up to 97% ee). (C) 2009 Elsevier Ltd. All rights reserved.

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