Lipase-catalysed kinetic resolutions of secondary alcohols in pressurised liquid hydrofluorocarbons

Three model secondary alcohols have been subjected to enzymatic kinetic resolution using three common lipases and a typical acyl donor. The resolutions were performed in two pressurised low-boiling hydrofluorocarbons, which are novel media for enzymatic reactions, and five conventional organic solvents. In general, higher yields, ee's and rates of reaction were observed in the hydrofluorocarbons. (C) 2009 Published by Elsevier Ltd.