期刊
TETRAHEDRON LETTERS
卷 50, 期 23, 页码 2716-2718出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2009.03.085
关键词
Diazo; N-H Insertion; Azacycle; Metathesis
资金
- Office of Research and Sponsored Programs
- BioMolecular Innovation and Technology group (BMIT)
- Department of Chemistry and Biochemistry, Ohio University
A series of five- to eight-membered nitrogen-containing heterocycles were prepared via a general and efficient one-pot, two-component sequence featuring rhodium-catalyzed insertion Of a vinyl-substituted alpha-diazocarbonyls into the N-H bond of a series of tert-butoxycarbonyl-(Boc)-protected amines, followed by ring-closing metathesis catalyzed by ruthenium benzylidene complexes, This methodology allows easy and convenient access to highly functionalized azacycloalkenes in moderate yields and excellent chemoselectivity in a single transformation. (C) 2009 Elsevier Ltd. All rights reserved.
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