期刊
TETRAHEDRON LETTERS
卷 50, 期 49, 页码 6764-6768出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2009.09.088
关键词
Fomitellic acid B; Titanium(III)-mediated radical cascade cyclization; Total synthesis; Triterpenoid
资金
- Japan Society for the Promotion of Science [18390010]
- Grants-in-Aid for Scientific Research [18390010] Funding Source: KAKEN
Herein, we describe the first total synthesis of fomitellic acid B (2), a potent inhibitor of DNA polymerases alpha and beta. There are two key features in this synthesis: (i) the AB ring system, with all requisite chiral centers, is stereoselectively constructed by means of titanium(III)-mediated radical cascade cyclization of epoxypolyene; and (ii) an enone moiety in the B-ring is generated by isomerization of an olefin followed by allylic oxidation. (C) 2009 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据