期刊
TETRAHEDRON LETTERS
卷 50, 期 20, 页码 2367-2369出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2009.02.207
关键词
Macrocycles; Oligopeptides; One-step synthesis; Aggregation
资金
- National Natural Science Foundation of China [2072127]
Two macrocyclic peptides 1a and 1b were synthesized directly from epsilon-aminoquinoliiiecarboxylic acid 2a and 2b, respectively. The preorganization of the uncyclized intermediates mediated by hydrogen bonding assisted the cyclization. The structures of 1a and 1b were characterized by H-1 and C-13 NMR spectroscopy and MALDI-TOF MS analysis. Solid state structure of la was investigated by single crystal X-ray studies. Their aggregation behaviors in solution were studied by both variable concentration and temperature H-1 NMR experiments. (C) 2009 Elsevier Ltd. All rights reserved.
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