期刊
TETRAHEDRON LETTERS
卷 50, 期 26, 页码 3277-3279出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2009.02.038
关键词
Marine natural product; Cortistatin A; Isoquinoline; Total synthesis
资金
- Ministry of Education, Culture, Sports, Science and Technology in Japan
- Suntory institute for bioorganic research (SUNBOR)
The highly stereoselective attachment of isoquinoline onto the steroidal framework of cortistatin A has been achieved. Our strategy features a Ce-mediated nucleophilic addition of an isoquinoline unit to the sterically congested ketone followed by formation of the phenyl thiocarbamate, and Subsequent stereoselective radical reduction. The new method results in a formal total synthesis of cortistatin A. (C) 2009 Elsevier Ltd. All rights reserved.
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