BiCl3 promoted aza-Prins type cyclization:: a rapid and efficient synthesis of 2,4-disubstituted piperidines

Several N-protected homoallyl amines and epoxides were subjected to an aza-Prins cyclization. A rapid and efficient BiCl3 promoted stereoselective synthesis of trans-2,4-disubstituted piperidine derivatives was achieved. (C) 2008 Elsevier Ltd. All rights reserved.