期刊
TETRAHEDRON LETTERS
卷 49, 期 49, 页码 7033-7036出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2008.09.135
关键词
Microwave-assisted chemistry; Quinazolin-4-ones; Formamide
资金
- Comite 76 de la Ligue Nationale contre le cancer
Generation of ammonia via thermal decomposition of formamide was Studied under microwave conditions to provide an efficient tool for the synthesis of nitrogen-containing heterocycles. Quinazolin-4-ones, which are known as building blocks for molecules with pharmaceutical interest, were chosen as examples. Our work confirms that reactants may have different behaviours under microwaves, depending on power input, reached temperature and pressure in the vials, Full control and fine tuning of these parameters are achievable using modern microwave technology. (c) 2008 Elsevier Ltd. All rights reserved.
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