Microwave-assisted solid acid-catalyzed one-pot synthesis of isobenzofuran-1(3H)-ones

A new, solid acid-catalyzed microwave-assisted environmentally benign synthesis of isobenzofuran-1(3H)-ones is described. Montmorillonite K-10 appeared to be an excellent catalyst for the condensation and successive lactonization reactions. Reaction of phthalaldehydic acid (2-arboxybenzaldehyde) with methylaryl and cyclic ketones was initiated by microwave irradiation and occurred in one step. The reactions were complete in 10-30 minutes providing excellent yields (90-98%). (c) 2008 Elsevier Ltd. All rights reserved.