The biosynthesis of sorbicillinoids in Trichoderma sp USF-2690:: prospect for the existence of a common precursor to sorbicillinol and 5-epihydroxyvertinolide, a new sorbicillinoid member

Biosynthetic feeding studies of [1-C-13], [2-C-13], and [1,2-C-13(2)]-labeled sodium acetates into 5-epihydroxyvertinolide, a new sorbicillinoid, gives an incorporation pattern that proves the gamma-lactone ring formation associated with a ring cleavage reaction of the precursor, a potential intermediate of sorbicillinol biosynthesis. (c) 2007 Elsevier Ltd. All rights reserved.