期刊
TETRAHEDRON LETTERS
卷 49, 期 45, 页码 6398-6400出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2008.08.064
关键词
Benzonaphthyridinedione; p56(lck) tyrosine kinase; Chaetominedione; Chaetomium sp.; Fungi; Marine micro-organism
资金
- DAAD [134.104401.212]
A marine fungal isolate, identified as Chaetomium sp., was cultivated and found to produce a novel benzonaphthyridinedione derivative, chaetominedione (1). In addition to the known fungal metabolites, 2-furancarboxylic acid (2) and 5-(hydroxymethyl)-2-furancarboxylic acid (3) were obtained. The structures of all the compounds were determined based on extensive spectroscopic measurements (1D and 2D NMR, MS, UV, and IR). The total extract and compound 1 had significant inhibitory activity toward p56(lek) tyrosine kinase (18.7% and 93.6% enzyme inhibition at 200 mu g/mL, respectively). (C) 2008 Elsevier Ltd. All rights reserved.
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