4.4 Article

Heck arylation of styrenes with arenediazonium salts: short, efficient, and stereoselective synthesis of resveratrol, DMU-212, and analogues

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TETRAHEDRON LETTERS
卷 49, 期 39, 页码 5668-5671

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PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2008.07.087

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  1. Research Supporting Foundation of the State of Sao Paulo [05/00721-3]
  2. CNPq
  3. FAPESP
  4. Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [05/00721-3] Funding Source: FAPESP

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Short, efficient, and stereoselective synthesis of the trans-stilbenes resveratrol, DMU-212, and analogues of both compounds are described. The synthesis of these important anti-cancer agents feature the palladium catalyzed Heck-Matsuda arylation of styrenes with arenediazonium tetrafluoroborates. (C) 2008 Elsevier Ltd. All rights reserved.

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