期刊
TETRAHEDRON
卷 70, 期 2, 页码 417-426出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2013.11.038
关键词
Diarylphosphane oxide; alpha,beta-Unsaturated pyrazolone; Catalyst-free; Organo-catalysis; Isosteviol derived thiourea
资金
- National Natural Science Foundation of China [21072145, 21272166]
- Program for New Century Excellent Talents in University [NCET-12-0743]
- Major Basic Research Project of the Natural Science Foundation of the Jiangsu Higher Education Institutions [13KJA150004]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
The synthesis of organophosphorus compounds is of great importance to industrial, agricultural, and pharmaceutical chemistry. In this paper, we have reported the synthesis of highly substituted pyrazole derivatives through P-C bond formation under catalyst-free conditions. On the other hand, the first catalytic asymmetric version of this reaction has also been developed under catalysis by an isosteviol derived thiourea organocatalyst. The optically active phosphorus-containing compounds have been obtained in good chemical yields with moderate enantioselectivities. (C) 2013 Elsevier Ltd. All rights reserved.
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