期刊
TETRAHEDRON
卷 70, 期 29, 页码 4425-4430出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2014.02.060
关键词
Talaromyces flavus; Talapolyesters A-F; 15G256 Polyesters; Wetland soil-derived fungus; Cytotoxicity
资金
- Technology of China [2012ZX09301002003]
- Natural Science Foundation of China [81373306]
- Guangdong Natural Science Funds [S2013050014287]
- program for New Century Excellent Talents in University [NCET-10-0120]
- Fok Ying Tung Education Foundation from the Ministry of Education of China [121039]
Six new polyesters, talapolyesters A-F (1-4, 14, and 16), together with 11 known ones 15G256 nu (5), 15G256 nu-me (6), 15G256 pi (7), 15G256 beta-2 (8), 15G256 alpha-2 (9), 15G256 alpha-2-me (10), 15G256 iota. (11), 15G256 beta (12), 15G256 alpha (13), 15G256 alpha-1 (15), and 15G256 omega (17), were isolated from the wetland soil-derived fungus Talaromyces flavus BYD07-13, and their structures were determined by NMR and MS spectroscopic data. Among them, 1-4 and 16 were assembled in a different manner from that of the known 256 polyesters. All the polyesters are composed of (R)-2,4-dihydroxy-6-(2-hydroxypropyl)benzoic acid and (R)-3-hydroxybutyric acid/(S)-3,4-dihydroxybutyric acid residues. The absolute configurations of the residues were determined by alkaline hydrolysis. The cytotoxicity against five tumor cell lines of these compounds was examined, and a tight structure-activity relationship is proposed. (C) 2014 Elsevier Ltd. All rights reserved.
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