期刊
TETRAHEDRON
卷 70, 期 17, 页码 2766-2775出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2014.02.081
关键词
Pyrazolol[1,5-a]quinolones; SNAr reaction; Knoevenagel cyclization; Dieckmann-Thorpe cyclization; Cascade reaction; Diversity
资金
- Grants-in-Aid for Scientific Research [25460147] Funding Source: KAKEN
A diversity-oriented method for the synthesis of novel poly-substituted pyrazolo[1,5-a]quinolines has been developed on the basis of an SNAr/Knoevenagel cyclization cascade reaction or an SNAr/Dieckmann- Thorpe cyclization cascade reaction. The methods provide a variety of poly-substituted pyrazolo[1,5-a]quinolines bearing an amino, alkyl or aryl substituent at the 5-position. In addition, a diversity-oriented method for the synthesis of 2-substituted pyrazolo[1,5-a]quinolines from a readily available 2-[[(trifluoromethyl)sulfonyl]oxy]pyrazolo[1,5-a]quinoline has also been disclosed.(C)2014 Elsevier Ltd. All rights reserved.
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