期刊
TETRAHEDRON
卷 70, 期 12, 页码 2129-2133出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2014.02.004
关键词
Polyketides; Bioactive secondary metabolites; Astrocystis sp.
资金
- Bioresources Research Network, National Center for Genetic Engineering and Biotechnology (BIOTEC)
Five new compounds, phthalide 1, dihydroisocoumarin 2, and 3, pyrone 4, and benzophenone 5, together with nine known compounds, 3,4-dihydro-4,5,8-trihydroxy-3-methylisocoumarin, sclerotinin A, methyl-8-hydroxy-6-methylxanthone-1-carboxylate, sydowinin A, conioxanthone A, 1,3,8-trihydroxy-6-methylxanthone, 1,8-dihydroxy-3-methoxy-6-methylxanthone, coniochaetone B, and xylaranol B, were isolated from the fungus Astrocystis sp. BCC 22166. Structures of these compounds were elucidated using NMR spectroscopic and MS spectrometric analyses. Compound I exhibited antibacterial activity against Bacillus cereus (IC50=12.5 mu g/mL) while compound 2 showed cytotoxicity to KB and Vero cells (IC50=22.6 and 48.2 mu g/mL). (C) 2014 Elsevier Ltd. All rights reserved.
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