期刊
TETRAHEDRON
卷 70, 期 13, 页码 2237-2245出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2014.02.042
关键词
Amide; Green chemistry; Ionic liquid; N-acylation; Solvent-free condition
资金
- National Nature Science Foundation of China [21302013]
- Nature Science Foundation of Jiangsu Province [BK2012207]
- Nature Science Foundation of Jiangsu Educational Department [12KJB150001]
- Foundation of Jiangsu Laboratory of Advanced Functional Material [12KFJJ008]
- China Postdoctoral Science Foundation [20100480990]
- Practice and Innovation Training Project for Jiangsu College Students
An eco-benign and highly efficient route for N-acylation of amines has been developed by treating amines with corresponding carboxylic acids in the presence of 2 mol % of heteropolyanion-based ionic liquids as catalysts under solvent-free conditions. This practical reaction could tolerate a wide range of substrates. Thus, various N-acylation products including N-acyl alpha-amino acid derivatives were obtained in moderate to excellent yields at 70 degrees C to 120 degrees C. Moreover, recycling studies revealed that heteropolyanion-based ionic liquids were easily reusable for this N-acylation. This method provides a green and much improved protocol over the existing methods.(c) 2014 Elsevier Ltd. All rights reserved.
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