期刊
TETRAHEDRON
卷 70, 期 4, 页码 936-943出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2013.12.009
关键词
Cyanobacteria; Microcystis; Micropeptins; Protease inhibitors; Natural products
资金
- Otto Monsteds Fond
- Israel Science Foundation [776/06]
Three new micropeptins, micropeptin KR1030, KR1002 and KR998 and the known microcyclamide GL546A were isolated from the extract of Microcystis sp. bloom material collected in Kabul Reservoir, Israel. The planar structures of the compounds were determined by homonuclear and inverse-heteronuclear 2D-NMR techniques as well as high-resolution mass spectrometry. The absolute configuration of the asymmetric centres of the amino acids was studied using Marfey's method for HPLC. The inhibitory activity of the compounds was determined for the serine proteases: trypsin, chymotrypsin and elastase. (C) 2013 Elsevier Ltd. All rights reserved.
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