期刊
TETRAHEDRON
卷 70, 期 41, 页码 7534-7550出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2014.08.003
关键词
Diversity-oriented synthesis; Pyrrolo[1,2-a]pyrazines; Cyclodehydration; Direct arylation; C-H activation
资金
- Nano Material Technology Development Program through the National Research Foundation of Korea (NRF) - Ministry of Education, Science and Technology
- Yonsei University
Diversity-oriented synthesis of a chemical library based on a pyrrolo[1,2-a]pyrazine core is described by using palladium-catalyzed direct C6 arylation of pyrrolo[1,2-a]pyrazines with various aryl bromides. The starting materials, pyrrolo[1,2-a]pyrazines, were easily synthesized by the base-mediated N-alkylation of pyrrole-2-carboxaldehyde with several 2-bromoacetophenones followed by dehydrative cyclization with incorporation of nitrogen by the action of ammonium acetate. Introduction of other functional groups on this chemical scaffold is also discussed herein. (C) 2014 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据