期刊
TETRAHEDRON
卷 70, 期 23, 页码 3647-3652出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2014.04.033
关键词
-
资金
- National Natural Science Foundation of China [21172085, 21032001]
beta-Lactam scaffold was fabricated regioselectively by a facile one-pot base-mediated synthesis. The reactions of bromoacetic acid 1, primary amines 2, isocyanides 3, and arylglyoxals 4 produced 2-aroyl-4-oxoazetidine-2-carboxamides 6 in good yields via a one-pot tandem Ugi condensation and intramolecular C-alkylation at room temperature in the presence of Cs2CO3. (C) 2014 Elsevier Ltd. All rights reserved.
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