期刊
TETRAHEDRON
卷 69, 期 27-28, 页码 5765-5771出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2013.04.075
关键词
Asymmetric cyclopropanation; Cyclopropanes; Donor/acceptor carbenoids; Dirhodium catalysis; Phenyldiazoacetate
资金
- National Institutes of Health [DA023224]
Catalytic enantioselective methods for the generation of cyclopropanes have been of long standing pharmaceutical interest. Chiral dirhodium(II) catalysts prove to be an effective means for the generation of diverse cyclopropane libraries. Rh-2(R-DOSP)(4) is generally the most effective catalyst for asymmetric intermolecular cyclopropanation of methyl aryldiazoacetates with styrene. Rh-2(S-PTAD)(4) provides high levels of enantioinduction with ortho-substituted aryldiazoacetates. The less-established Rh-2(R-BNP)(4) plays a complementary role to Rh-2(R-DOSP)(4) and Rh-2(S-PTAD)(4) in catalyzing highly enantioselective cyclopropanation of 3-methoxy substituted aryldiazoacetates. Substitution on the styrene has only moderate influence on the asymmetric induction of the cyclopropanation. (C) 2013 Elsevier Ltd. All rights reserved.
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