期刊
TETRAHEDRON
卷 69, 期 47, 页码 9931-9938出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2013.09.082
关键词
Pyranopyrazoles; Multicomponent reaction; One-pot synthesis; Meglumine; Biodegradable material
资金
- National Natural Science Foundation of China [21272053, 21072042, 20872025]
- Nature Science Foundation of Hebei Province [B2011205031]
- Training Programs of Innovation and Entrepreneurship for Undergraduates of Hebei Province [201310094021]
Meglumine, a bio-based chemical, was demonstrated to be a highly efficient and reusable catalyst for the synthesis of a series of pyranopyrazole derivatives via a one-pot, four-component reaction of carbonyl compound or isatin, hydrazine hydrate, malononitrile, and beta-keto ester in EtOH-H2O. The catalyst was found to work extremely for aldehydes, ketones or isatins at room temperature to give the corresponding dihydropyrano[2,3-c]pyrazole or spiro[indoline-3,4'-pyrano[2,3-c]pyrazole] derivatives in high yields. The salient features of this new methodology are broad substrate scope, room temperature reaction conditions, short reaction times, high yields, easy work-up process, reusability of catalyst, and the absence of hazardous organic solvents. (C) 2013 Elsevier Ltd. All rights reserved.
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