期刊
TETRAHEDRON
卷 69, 期 5, 页码 1583-1589出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2012.12.001
关键词
Officinatrione; (17S)-17,18-seco-Lup-19(21)-ene-3,18,22-trione; 3 beta-Acetoxy-18 alpha,19 alpha-epoxylupan-21 beta-ol; 18 alpha,19 alpha-Epoxy-21 beta-hydroxylupan-3-one; Lup-18-ene-3,21-dione; Lupa-18,21-dien-3 beta-yl acetate triterpene; Root; Taraxacum officinale; L1210 cell line
Novel 5 lupane-type of triterpenois, i.e., 3 beta-acetoxy-18 alpha,19 alpha-epoxylupan-21 beta-ol (1), 18 alpha,19 alpha-epoxy-21 beta-hydroxylupan-3-one (2), lup-18-ene-3,21-dione (3), lupa-18,21-dien-3 beta-yl acetate (4), and (17S)-17,18-seco-lup-19(21)-ene-3,18,22-trione (5), named officinatrione, as well as 16 known compounds from the roots of Taraxacum officinale collected in Takatsuki city, Osaka, Japan. Of the above compounds, 5 was the first lupane-type triterpene, of which the D-ring was open to form a nine-membered ring. Compounds 2 and 5 exhibited moderate cytotoxic activities against L1210 cell line (IC50 10.5 and 10.1 mu M). (c) 2012 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据