期刊
TETRAHEDRON
卷 69, 期 18, 页码 3706-3713出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2013.03.006
关键词
Marine compounds; Polyketide endoperoxides; Plakinastrella mamillaris; Antiplasmodial activity
资金
- MIUR
Plakortides R-U, four new polyketide endoperoxides, have been isolated from the marine sponge Plakinastrella mamillaris. Their structures were elucidated on the basis of extensive NMR spectroscopic (H-1 and C-13, COSY, HSQC, HMBC, and ROESY) and MS analyses and by chemical methods. In addition, a new method for the unambiguous stereochemical elucidation of 3,6-disubstituted 1,2-dioxines, frequently isolated from Plakinidae sponges, is reported. Pharmacological analysis demonstrated that plakortide U is endowed with in vitro antiplasmodial activity against a chloroquine-resistant strain. (C) 2013 Published by Elsevier Ltd.
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