期刊
TETRAHEDRON
卷 69, 期 48, 页码 10284-10291出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2013.10.026
关键词
3-Chloropyridine; 3-Bromopyridine; Lithiation; Density functional calculation
资金
- CSIR, New Delhi, India
- SAP by UGC, New Delhi
The BF3-directed lithiation of 3-chloro- and 3-bromopyridine (1a and 1b, espectively) has been investigated. The reactions of 3-chloro- or 3-bromopyridine-BF3 adduct with LDA (1.3/1.1 equiv) followed by quenching with benzaldehyde or iodine exclusively gave the C-2 substituted products. However, when 2.2 equiv of LDA and dimethyl disulfide was used, a C-6 substituted product was obtained. Dilithiation of 1a and 1b has been studied with and without the involvement of BF3 complexation. The role of Li...F(BF3) interactions has been investigated by experimental and DFT calculations. (C) 2013 Elsevier Ltd. All rights reserved.
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