A new strategy for facile synthesis of tetrasubstituted pyridine derivatives

A facile and efficient reaction of alpha-azidomethyl aryl ketones and dialkyl but-2-ynedioate offers a new strategy for the synthesis of tetrasubstituted pyridines in mild condition. This method tolerates a range of functionality and a possible mechanism is proposed. Crown Copyright (C) 2013 Published by Elsevier Ltd. All rights reserved.