期刊
TETRAHEDRON
卷 69, 期 20, 页码 4139-4145出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2013.02.095
关键词
Limonoids; Walsura chrysogyne; Walsogynes B-G; Density functional theory
资金
- Ministry of Education, Culture, Sports, Science, and Technology of Japan
- Grants-in-Aid for Scientific Research [25460139] Funding Source: KAKEN
Six new limonoids, Walsogynes B (1)-G (6), were isolated from the barks of Walsura chrysogyne, and their structures were determined on the basis of NMR and MS spectroscopic analyses in combination with NMR chemical shifts calculations. Walsogynes (1)-E (4) were concluded to be 11,12-seco limonoids sharing a unique dodecahydronaphtho[1,8-bc:5,4-b'c']difuran skeleton, and walsogynes F (5) and G (6) to be 11,12-seco limonoids with a dodecahydro-1H-naphtho[1,8-bc:3,4-c']difuran skeleton. Their absolute configurations were assigned through comparison of the calculated and experimental CD spectra. Walsogynes showed a moderate in vitro cytotoxic activity against various cancer cell lines. (C) 2013 Elsevier Ltd. All rights reserved.
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