期刊
TETRAHEDRON
卷 69, 期 51, 页码 10797-10804出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2013.10.095
关键词
Prosuberites laughlini; Cyclic peptides; Caribbean sponge; Cytotoxicity; Peptides
资金
- ESI-MS/MSn data
- NCI for cytotoxicity assays
- NIH [1SC1GM086271-01A1]
- UPR-RISE Fellowship Program
A new investigation of the active sponge extracts of Prosuberites laughlini collected off the West coast of Puerto Rico has yielded three new cyclic heptapeptides, namely euryjanicins E (1)-G (3), containing multiple phenylalanine and proline residues. In CDCl3 solution, each euryjanicin F (2) and G (3) exists as an inseparable complex mixture of conformational isomers. The molecular structures of 1-3 were elucidated by a combination of chemical degradation, extensive ESI-MS/MSn analyses, and 20 NMR methods. The elucidation of the absolute configuration was achieved by HPLC following analysis of the acid hydrolysates after derivatization with Marfey's reagent. When assayed against the National Cancer Institute 60 tumor cell line panel, the new cyclic peptides did not display significant in vitro cytotoxicity. (C) 2013 Elsevier Ltd. All rights reserved.
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