期刊
TETRAHEDRON
卷 69, 期 13, 页码 2799-2806出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2013.01.070
关键词
Dendron; Poly(propylene imine); Proton-sponge; Thiol anchoring; Nitrile reduction; Borane dimethyl sulfide
资金
- AACR/PanCAN [08-20-25-DANI]
- Department of Defense [PC081299]
The synthesis of a novel third generation poly(propylene imine) dendron (PPI dendron) is described herein. The dendritic focal point was attached to a tetraethylene glycol spacer that was terminated with a Tmob-protected thiol in order to both avoid any side-reaction during functionalization of dendritic branches as well as enable convenient integration of the dendron into diverse complex systems. The protonation of the final PPI dendron at pH 4-5 is predicted to induce lysosomal degradation through the proton-sponge effect, and therefore enable cytosolic release. These features make the prepared dendron a very convenient building-block for use in the construction of larger systems, such as multifunctional drug delivery vehicles. (C) 2013 Elsevier Ltd. All rights reserved.
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