期刊
TETRAHEDRON
卷 69, 期 12, 页码 2555-2559出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2013.01.068
关键词
alpha-Conotoxin MII; Soluble tag; Liquid-phase peptide synthesis; Hydrophobic benzyl amine; Disulfide bond
资金
- Ministry of Education, Culture, Sports, Science and Technology of Japan
- Grants-in-Aid for Scientific Research [23780113] Funding Source: KAKEN
Oxidative disulfide bond formations have been applied to soluble-tag-assisted method successfully to realize the total synthesis of alpha-conotoxin MII (4) that comprises 16 amino acid residues and possesses 2 disulfide bonds. Orthogonal peptide folding using DEAD and iodine oxidations in combination with Mmt and Acm groups for the side chain protection of cysteines could be carried out with no peptide aggregation. (C) 2013 Elsevier Ltd. All rights reserved.
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