Facile, efficient and diastereoselective synthesis of α-hydrazine tetrazoles through a novel one-pot four-component reaction

A novel and efficient method for the diastereoselective synthesis of alpha-hydrazine tetrazoles via an isocyanide-based multicomponent reaction is reported in good yields. The alpha-hydrazine tetrazoles were obtained by a facile azide Ugi four-component reaction (U-4CR) using cyclic ketones, trimethylsilyl azide, hydrazides, and corresponding isocyanide without any catalyst and with high bond forming efficiency at room temperature. (C) 2013 Elsevier Ltd. All rights reserved.