期刊
TETRAHEDRON
卷 68, 期 4, 页码 982-987出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2011.11.095
关键词
Marine natural product; Sea hare; Aplyronine; Isolation; Structure; Cytotoxicity
资金
- Ministry of Education, Culture, Sports, Science, and Technology (Japan) [04403009, 03640472]
- Fujisawa Foundation
- Shorai Foundation for Science and Technology
- Naito Foundation
- Ciba-Geigy Foundation (Japan) for the Promotion of Science
- Asahi Glass Foundation
- Ono Pharmaceutical Co.
- Japan Society for the Promotion of Science
- Grants-in-Aid for Scientific Research [21221009, 03640472, 23102014, 04403009, 23310148] Funding Source: KAKEN
Five cytotoxic macrolides. aplyronines D-H (4-8), were isolated from the Japanese sea hare Aplysia kurodai. They are new congeners of the antitumor compound aplyronine A (1), which was previously isolated from the same organism. Their structures were determined by spectroscopic analysis (NMR and MS). The cytotoxicity of these new compounds was evaluated in comparison with that of aplyronines A C (1-3), suggesting the importance of the 7-O-seryl ester group for mediating the potent cytotoxicity of aplyronines. (C) 2011 Elsevier Ltd. All rights reserved.
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