期刊
TETRAHEDRON
卷 68, 期 13, 页码 2899-2905出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2012.01.067
关键词
Nitriles; Oximes; Catalysis; Phosphonium salts; Phosphine oxides
资金
- University of Nottingham [NF5012]
- The Nuffield Foundation Bursary
- EPSRC [EP/J000868/1, EP/H018034/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/J000868/1, EP/H018034/1] Funding Source: researchfish
A metal-free catalytic method for the conversion of aromatic and aliphatic aldoximes to nitriles at room temperature using oxalyl chloride (1.2 equiv) in combination with 5 mol % of triphenylphosphine oxide is reported. Of the many potential pathways leading from oxime to nitrile a manifold involving chlorophosphonium salt-catalysed decomposition of oxime chlorooxalates formed in situ is shown to be operative. (C) 2012 Published by Elsevier Ltd.
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