期刊
TETRAHEDRON
卷 68, 期 25, 页码 5087-5094出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2012.04.041
关键词
Pyrrolo[3 ',2 ':4,5]thiopyrano[3,2-b]pyridin-2-one; Angelicin; Antiproliferative activity; Enaminoketones
资金
- Ministero dell'Istruzione dell'Universita e della Ricerca
A series of pyrrolo[3',2':4,5]thiopyrano[3,2-b]pyridin-2-ones 4 was prepared in good yields by reacting enaminoketones with cyanomethylene active compounds such as phenylsulfonylacetonitrile, benzoylacetonitrile, and malononitrile. Derivatives of the title ring system were tested by the National Cancer Institute of Bethesda against a panel of about 60 human tumor cell lines, and one of them showed inhibitory activity against all cancer cell lines reaching on 48% of them GI(50) values at submicromolar level and on the majority of the remaining ones in the low micromolar concentration. (C) 2012 Elsevier Ltd. All rights reserved.
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