期刊
TETRAHEDRON
卷 68, 期 3, 页码 872-877出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2011.11.037
关键词
Azidopeptides; Tetrapeptides; alpha-Trifluoromethyl-alpha-amino acids; alpha-Aminophosphonates; Click chemistry
A convenient synthetic pathway to novel functionalized tetrapeptides containing the 1,2,3-triazole moiety is described. The target molecules were obtained by the reaction of fluorinated alpha-amino acids or alpha-aminophosphonates with azidopeptides via Cu(I)-catalyzed Huisgen cycloaddition reaction (click chemistry). The synthesized tetrapeptides may find important applications in biomedical chemistry as potential drugs. (C) 2011 Elsevier Ltd. All rights reserved.
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