4.4 Article

Synthesis of bicyclic 2,6-diketopiperazines via a three-step sequence involving an Ugi five-center, four-component reaction

期刊

TETRAHEDRON
卷 68, 期 39, 页码 8222-8230

出版社

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2012.07.064

关键词

Ugi reaction; Multicomponent reaction; Amide N-detertbutylation; Isocyanide; 2,6-Diketopiperazine

资金

  1. Committee for Scientific Research, Poland [N N405 623138]
  2. Medical University of Warsaw

向作者/读者索取更多资源

A three-step sequence involving an Ugi five-center, four-component reaction (U-5C-4CR), amide N-detertbutylation and cyclocondensation has been developed for easy access to diverse bicyclic 2,6-diketopiperazine (2,6-DKP) derivatives. In the key step, aromatic aldehydes were successfully coupled with cyclic alpha-amino acids and isocyanides in the course of U-5C-4CR. Boron trifluoride-acetic acid complex was developed as a new N-detertbutylating agent effective at rt. (C) 2012 Elsevier Ltd. All rights reserved.

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