期刊
TETRAHEDRON
卷 68, 期 2, 页码 559-565出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2011.11.001
关键词
Marine sponge; Rhabdastrella globostellata; Globostelletins J-R; Structural elucidation; Protein kinase inhibition
资金
- NSFC [30672607]
- National Hi-Tech 863-Projects [2010DFA31610]
- BMBF/MOST
Nine new isomalabaricane-type triterpenoids namely globostelletins J-R (1-9) were isolated from the marine sponge Rhabdastrella globostellata. Their structures were established on the basis of extensive spectroscopic data analysis including IR, MS, 1D and 2D NMR, and CD spectra. Globostelletins J-R are characterized by the presence of an unusual cyclopentane unit linked at different positions of sidechains. These unprecedented structures enriched a number of new skeletons in isomalabaricane family. The biogenetic relationship of the isolated compounds is postulated. All compounds were tested for the inhibitory activities against human tumor-related protein kinases. (C) 2011 Elsevier Ltd. All rights reserved.
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