期刊
TETRAHEDRON
卷 68, 期 42, 页码 8767-8772出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2012.08.007
关键词
Porphyrins; Anticancer agents; Imaging agents; Singlet oxygen; Photodynamic therapy; Photosensitizers
资金
- FCT/QREN/FEDER Portugal [SFRH/BD/65699/2009]
- FCT [REEQ/481/QUI/2006]
- FEDER, Portugal
- International PhD-studies program at the Faculty of Chemistry Jagiellonian University within the Foundation for Polish Science MPD Program
- EU European Regional Development Fund
- Ministry of Science and Higher Education for Iuventus Plus grant [IP2011009471]
- [PEST/C/QUI/UI 0313/2011]
- [PTDC/QUI-QUI/112913/2009]
- [POCI-2010]
A set of amphiphilic fluorinated porphyrins appended with sulfonate ester groups were synthesized and fully characterized. The reaction proceeds efficiently, with high yields, with an improved methodology. Their potential use as imaging and phototherapeutic agents was assessed measuring relevant photophysical properties. It is shown that these porphyrins have good photostability, long triplet lifetimes (between 47 mu s and 102 mu s), high singlet oxygen quantum yields (0.74 <= FD <= 1.00), low fluorescence quantum yields (<0.04) and sharp 19F NMR peaks. The data on the new meso(sulfonate ester fluoroaryl) porphyrins illustrate the potential of perfluorinated sulfonate esters to improve physical properties relevant for cancer imaging and photodynamic therapy. (C) 2012 Elsevier Ltd. All rights reserved.
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