期刊
TETRAHEDRON
卷 68, 期 34, 页码 6881-6886出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2012.06.018
关键词
Smenospongia; Thorectidae; Sesquiterpene hydroquinones; Brominated indole alkaloids; Cytotoxic activities
资金
- Center of Excellence on Environmental Health and Toxicology (EHT), PERDO, Ministry of Education
- Chulabhorn Research Center, Institute of Molecular Biosciences, Mahidol University
6'-lodoaureol, an iodo-sesquiterpene hydroquinone, 6'-aureoxyaureol, a bissesquiterpene hydroquinone, and four brominated indole alkaloids 3-6 were isolated from the Thai sponge Smenospongia sp. Additionally, four known sesquiterpene hydroquinones 12-15, ten known brominated indole alkaloids 7-11, 17-18, and 20-22, ergosterol, and furospinosulin-1 were also isolated. Compound 1 is the first reported iodo-sesquiterpene hydroquinone and compounds 7-11 were isolated for the first time from natural sources. The structures were characterized by spectroscopic analyses as well as comparison with literature data. Several of these metabolites were evaluated for cytotoxic activity against seven tumor cell lines. (C) 2012 Elsevier Ltd. All rights reserved.
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