期刊
TETRAHEDRON
卷 68, 期 5, 页码 1401-1406出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2011.12.035
关键词
Pyridinium ylide; 2,3-Dihydrofurans; Michael reaction; O-Alkylation; One-pot process
资金
- National Science Council of ROC [NSC-98-2113-M-006-003-MY2]
A one-pot three-component process for the synthesis of highly functionalized 2,3-dihydrofurans from 1,3-dicarbonyl compounds, aromatic aldehydes, and N-phenacylpyridinium bromides has been developed. Benzylidene 1,3-dicarbonyl compounds could be generated in situ from aromatic aldehydes and 1,3-dicarbonyl compounds and then reacted smoothly with N-phenacylpyridinium bromides to produce 2,3-dihydrofurans in moderate to good yields. Piperidine/acetonitrile is the optimal condition for this process. To increase the efficiency of this reaction, this one-pot process was also conducted solvent-free under classical heating conditions and grinding conditions. (C) 2012 Elsevier Ltd. All rights reserved.
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