期刊
TETRAHEDRON
卷 68, 期 47, 页码 9694-9700出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2012.09.060
关键词
Scleronephthya gracillimurn; Sclerosteroids; O-Tolylthiocarbamate; Cytotoxic activity; Anti-inflammatory activity
资金
- National Science Council of Taiwan [NSC-100-2320-B-110-001-MY2]
Nine new steroids, sclerosteroids A-1 (1, 5, 6, 8-13), along with 18 known metabolites (2-4, 7, 14-27), were isolated from the soft coral Scleronephthya gracillimum. These structures were elucidated on the basis of detailed spectroscopic analysis. The absolute configurations of sugar moieties in steroidal glycosides 10-13 were determined by HPLC analysis of the o-tolylthiocarbamate derivatives of the liberated sugars from hydrolysis of these steroidal giycosides. Cytotoxic and anti-inflammatory activities of these compounds were measured in vitro. (c) 2012 Elsevier Ltd. All rights reserved.
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