期刊
TETRAHEDRON
卷 68, 期 47, 页码 9738-9744出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2012.09.040
关键词
Marine sponge; Age las sp.; Diterpene alkaloid; Bromopyrrole alkaloid; Age lasines O-U; Antimicrobial activity
资金
- Akiyama Life Sience Foundation
- Suhara Memorial Foundation
- Ministry of Education, Culture, Sports, Science, and Technology of Japan
New diterpene alkaloids, agelasines O-U (1-7), have been isolated from an Okinawan marine sponge Agelas sp. The gloss structures and relative stereochemistries of 1-7 were elucidated from the spectroscopic data. Agelasines O-R (1-4) were the third examples of diterpene alkaloid with a 9-N-methyladenine and a pyrrole units. Agelasine O (1) has a halimane skeleton, while agelasines P-R (2-4) have a clerodane skeleton. Agelasines S-U (5-7) were new diterpene alkaloids with a 9-N-methyladenine unit consisting of a halimane skeleton, a labdane skeleton, and a clerodane skeleton, respectively. Agelasines O-R (1-4) and T (6) showed antimicrobial activities against several bacteria and fungi. (c) 2012 Elsevier Ltd. All rights reserved.
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