期刊
TETRAHEDRON
卷 68, 期 42, 页码 8704-8711出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2012.08.025
关键词
Nucleophilic addition; Aldehydes; N,N-Diisopropylcarbamoyl; Regioselective protection; 1,2-Diols
资金
- National Natural Science Foundation of China [81102306]
1-(N,N-Diisopropylcarbamoyloxy)-1-tosyl-methane (CbOCH2Ts, Cb=N,N-diisopropylcarbamoyl) was readily prepared from p-ToISH, paraformaldehyde and CbCl. With the dual activation of CbO- and Ts-substitutions, deprotonation of CbOCH2Ts could be effected not only by n-BuLi, but also by Grignard reagents. Upon deprotonation, the title compound adds to various carbonyl structures. By choosing proper organometallic reagents for consecutive steps, the addition intermediate undergoes in situ conversions to efficiently yield regioselectively O-Cb protected and unprotected 1,2-diols. (C) 2012 Elsevier Ltd. All rights reserved.
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