Efficient one-pot synthesis of cyclic β-enaminoamides by thermal Wolff rearrangement of cyclic 2-diazo-1,3-dicarbonyls and conversion to uracil derivatives

This paper describes simple and efficient approaches for the preparation of beta-enaminoamides through thermal Wolff rearrangement of cyclic diazodicarbonyls followed by trapping with various amines. The synthesized beta-enaminoamides were readily converted into uracil derivatives. (C) 2012 Elsevier Ltd. All rights reserved.