期刊
TETRAHEDRON
卷 68, 期 10, 页码 2357-2362出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2012.01.024
关键词
Artificial receptor; Phosphorylated peptides; CTD peptides; Isothermal titration calorimetry
资金
- National Natural Science Foundation of China [20634030, 21104034]
In this study, a receptor for phosphorylated peptide was developed. The receptor contains Zn2+-dipicolylamine (Zn-Dpa) moiety at one end and guanidiniocarbonyl pyrrole at the other. The association between the receptor and CTD (carboxy-terminal domain of RNA polymerase II) peptides with different phosphorylated patterns was investigated by isothermal titration calorimetry and molecular docking, and the receptor showed much higher affinity towards bis-phosphorylated CTD peptide with affinity constant K=1.09 x 10(5). (C) 2012 Elsevier Ltd. All rights reserved.
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