期刊
TETRAHEDRON
卷 68, 期 39, 页码 8256-8260出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2012.07.056
关键词
One-pot reaction; Domino reaction; Heterocycle; Pyrrole; Isatin; Electron-deficient alkyne
资金
- National Natural Science Foundation of China [21172189]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
An efficient synthetic method for the pentasubstituted pyrroles was successfully developed via the one-pot domino reactions of arylamines, acetylenedicarboxylates, and 3-phenacylideneoxindoles. The reaction mechanism involved the sequential Michael addition and ring closure of the in situ generated beta-active enamino ester. (C) 2012 Elsevier Ltd. All rights reserved.
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