期刊
TETRAHEDRON
卷 68, 期 1, 页码 197-203出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2011.10.066
关键词
Click chemistry; G-quadruplex; Telomerase inhibitor; Cancer; Telomestatin
资金
- AICR
- EPSRC
- University of Nottingham
A library of hybrid oxazole-triazole based compounds containing contiguously linked aromatic units were synthesised as G-quadruplex binding ligands. The design of these ligands was based upon combining features of our first generation of G-quadruplex bis-triazole ligands and the natural product telomestatin. The syntheses and biophysical studies of these ligands are described. (C) 2011 Elsevier Ltd. All rights reserved.
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