期刊
TETRAHEDRON
卷 68, 期 36, 页码 7275-7279出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2012.07.005
关键词
Marine natural products; Laurencia; Marine polyether; NMR spectroscopy; Chemical synthesis
资金
- MAREX [KBBE-3-245137, SAF2011-28883-03-01, SAF2008-02251]
- Red Tematica de Investigacion Cooperativa en Cancer, Instituto de Salud Carlos III [RD06/0020/1037]
- Fondo Europeo de Desarrollo Regional of the European Union
- Junta de Castilla y Leon [CSI052A11-2]
- GR15-Experimental Therapeutics and Translational Oncology Program
- Consejo Nacional de Ciencia y Tecnologia [168081]
- SEGAI-ULL fellowship
Two new cytotoxic oxasqualenoids, saiyacenols A and B, were isolated from the red alga Laurencia viridis and their structures elucidated by spectroscopic methods and chemical correlation with the well-known compound dehydrothyrsiferol. The new compounds share an important part of their structure with thyrsiferol and aplysiols B and C. Isolation of the saiyacenols concludes the controversy about the configuration of aplysiols, correcting the structure of aplysiol B. Our results illustrate the current limitations of NMR J-based methods when approaching quaternary carbons and demand a reappraisal of rational biogenetic proposals in structural elucidation. (C) 2012 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据